Equipes

Equipe 1: Code W0414101  |  IMIMT
Immunomodulation & Immunothérapie  | Immunomodulation & Immunotherapy

CHEF D'EQUIPE - TEAM LEADER

Prof. Mourad Aribi, PhD, Dr. Hab., Immunol Ther., HDR Resume
ORCID ID: 0000-0002-6522-7252

Editorial Role: Associate and Review Editor for the journal Frontiers in Immunology, the official Journal of the International Union of Immunological Societies (IUIS): loop

Membres de l'Equipe - Team Members

F
Fadila Boudjelal, PhD student
Farah Djelti, PhD, Assoc. Prof.
H
Hicham Zerrouk, PhD student
Houria Bennaradj, PhD student
I
Imene Belhassena, PhD
L
Lamia Ysmail Dahlouk, PhD, Assoc. Prof.
M

Maroua Miliani, PhD, Assoc. Prof.

Moudjahed Al-Ddafari, PhD, 1974-2022 

Mouna Nouar, PhD, Researcher & Adjunct Academic Fellow

R
Rabia Messali, MSc., MSc., Engr. Lab
S
Slimane Brikhou, PhD student
Soumeya Benammar, PhD student
T
Taleb Aridj, PhD student
W
Wafa Nouari, PhD, Assoc. Prof.

Warda Meziane, PhD, Assoc. Prof.
Y
Yassamine Seladji, PhD student
Z
Zeyneb Hadjidj, PhD, Assoc. Prof.

Zineb Mekkaoui, PhD student

Focus & Axe de recherche

Thèmes :

- Dérégulation de la fonction des cellules immunitaires.
- Evaluation de l'efficacité des thérapies immunomodulatrices.

  • CONTEXTE GENERAL Recherche et compréhention des mécanismes de la dérégulation de la fonction des cellules immunitaires, pour y remédier par des thérapies immunomodulatrices, dans des conditions pathologiques. L'immunothérapie est de plus en plus souvent envisagée, ou déjà utilisée, pour ces pathologies. Il s'agit d'un domaine en pleine expansion et il est important que des Equipes algériennes se positionnent sur ce sujet, en partenariat avec des Equipes internationales. Les développements technologiques attendus peuvent être considérables.
  • TRAVAUX RECENTS Nos travaux actuels sont focalisés plus particulièrement sur les cellules de l'immunité innée (cf. Immunomodulation of innate immune cells response and cell-based immunotherapy).

Activités scientifiques & livrables

Modèles d'études  | Study models 

Modèle 1 : cellules endothéliales humaines
Modèle 2 : monocytes en co-culture avec les cellules autologues primaires humaines du cancer du sein (ER-/PR-/HER2+)
Modèle 3 : monocytes classiques (moM1, CD14++CD16-), non-classiques (moM3, CD14+CD16++), et intermédiaires (moM2, CD14++CD16+), isolés de patients lors d’un infarctus de myocarde
Modèle 4 : cellules NK en co-culture avec les globules rouges autologues durant différents types de cancer solide
Modèle 5 : monocytes isolés de patients atteints du diabète de type 1 récent
Modèle 6 : macrophages dérivés de monocytes humains sous l'action de GM-CSF 
Modèle 7 : macrophages classiques M1, pulsés avec les cellules nécrotiques de la lignée Jurkat, en présence d'un adjuvant

Points essentiels [Highlights]  | our New findings

Nous avons montré pour la première fois que :
1. Durant l’infection à S. aureus, le traitement à la vitamine C (AscH2) favorise la survie, la fonction et la réparation/l'activation du cycle cellulaire des cellules endothéliales humaines, et inverse la libération d'ICAM-1 soluble et la voie métabolique de l'énergie cellulaire en rapport avec l’absorption du glucose. Aussi, la forme réduite de la vitamine C prévient l’exacerbation de la réponse inflammatoire, tout en induisant l’augmentation de l’activité bactéricide. (PubMed: PMID 33676147. URL). 

2. Les biomarqueurs des activités fonctionnelles phénotypiques des monocytes sont modifiés après co-culture avec des cellules de cancer du sein humain primaires (ER-/PR-/HER2+). Le traitement avec la metformine entraîne une libération accrue de la cytokine anti-tumorale IFN-γ et du calcium libre intracellulaire (ifCa2+), et une nécrose cellulaire accrue lors de l'interaction entre les cellules du cancer du sein et les monocytes autologues. (PubMed: PMID 33108409. URL).

3. L'aspirine immunomodule les activités fonctionnelles des monocytes, favorise leur commutation (switch) vers un phénotype classique (moM1, CD14++CD16-), induit une baisse de l'activité iNOS et une hausse de l'activité de l'arginase lors d'un infarctus du myocarde. (PubMed:  PMID 32172203. URL). 

4. La stagnation cellulaire serait fortement impliquée dans l'apoptose des cellules NK périphériques, ainsi que dans la commutation vers un phénotype régulateur NK Foxp3+ lors de leur interaction avec les globules rouges. Le mouvement cellulaire peut être l'une des approches potentielles requis pour stimuler les activités et la survie de ces cellules au cours d'un cancer solide, en régulant négativement les niveaux d'apoptose associée à p53 et d'expression d'ERK. (PubMed: PMID 32027874. URL).

5. Le rituximab (RTX, un anticorps monoclonal chimérique anti-CD20) inverse les anomalies des activités fonctionnelles des monocytes, ainsi que leur production de cytokines pro-inflammatoires au début du diabète de type 1 humain. (PubMed: PMID 31322069. URL).

6. La metformine combinée au sélénite de sodium immunomodule le burst respiratoire et la phagocytose du macrophage dans les conditions normales, régule sa capacité de lyse intracellulaire et d'expression de la NADH déshydrogénase (complexe I), et induit sa commutation vers le phénotype "M2"(Arginase, ARG1). La metformine et le sélénite de sodium modulent différemment l'expression de CD14, CD80, CD86 et HLA-DR. (PubMed: PMID 31108386. URL).

7.  La thymoquinone (TQ; 2-isopropyl-5-méthyl -1,4-benzoquinone, C10H12O2), peut être proposée comme un adjuvant puissant dans une approche vaccinale contre la leucémie aiguë lymphoblastique T, promouvant les réponses des macrophages M1, classiquement activés, pulsés avec des lysats de lignées de cellules Jurkat nécrotiques (NecrJCL), et la production de cytokines antitumorales au cours de l'interaction avec les cellules T CD4+ autologues. (PubMed: PMID 30422744. URL). 
(cf. Figure 1.)

Figure 1. Immunomodulation of innate immune cells response and cell-based immunotherapy in inflammatory conditions – cancer – autoimmune type 1 diabetes – myocardial infarction autoinflammatory disease – Figure en haute résolution
PART II
Figure 2. Immunomodulation of innate immune cells response and ex vivo immunotherapy in inflammatory conditions – autoimmune type 1 diabetes – infection – Figure en haute résolution
PART III
Figure 3. Infection and inflammatory condition – cancer -  primary immunodeficiency –  Figure en haute résolution

Publications

2023
  • Mourad Aribi*, Franck JD Mennechet, Chafia Touil-Boukoffa. Editorial: The role of vitamin D as an immunomodulator. Front Immunol 2023; 14:1186635. doi: 10.3389/fimmu.2023.1186635. [*Corresponding author]
  • Mouna Nouar, Maroua Miliani, Imène Belhassena, Ahlam Fatmi, Mourad Aribi*. Sodium selenite modulates global activation of proinflammatory M1-like macrophages, necroinflammation and M1-like/M2-like dichotomy at the onset of human type 1 diabetes. Endocr Metab Immune Disord Drug Targets 2023; 23: 1104-1117. doi: 10.2174/1871530323666230201135916. [*Corresponding author]
  •  Xiao Peng, Moudjahed Saleh Al-Ddafari, Andres Caballero-Oteyza, Chahrazed El Mezouar, Pavla Mrovecova, Saad Eddin Dib, Zoheir Massen, Mohammed Chems-Eddine Smahi, Faiza Aldaffari, Rafik Terki Hassaïne, Gérard Lefranc,  Bodo Grimbacher*,+, Mourad Aribi*,+. A Next Generation Sequencing (NGS)-based approach to diagnosing Algerian patients with suspected Inborn Errors of Immunity (IEIs). Clin Immunol 2023; 256:109758. doi: 10.1016/j.clim.2023.109758. [Corresponding author, *Shared last authors]
  • Slimane Brikhou, Wafa Nouari, Sofiane Bouazza, Zakaria Benzian, Kheira Talha, Chahrazed El Mezouar, Mourad Aribi*. Dietary vitamin D intake and sun exposure are not associated with type 1 diabetic schoolchildren and adolescents: A first report in Algeria. Med J Nutrition Metab 2023, 16: 105-122, 20232023; 16:105-122. doi: 10.3233/MNM-230012 [Corresponding author]
2022
  •  Ahlam Fatmi, Nafissa Chabni, María Cernada, Máximo Vento, María González-López, Mourad Aribi#, Federico V. Pallardó, José Luis García-Giménez. Clinical and immunological aspects of microRNAs in neonatal sepsis. Biomed Pharmacother 2022; 145: 112444. doi: 10.1016/j.biopha.2021.112444. [#Senior author]
  •  Fella Rostane, Nidel Sari, Ilyes Bali, Rabia Messali, Zeyneb Hadjidj, Maroua Miliani, Imene Belhassena, Chahrazed El Mezouar, Mourad Aribi*.  Combination therapy of metformin with sodium selenite reverses effects of monotherapy on nitric oxide production, IL-1β and TNF-α release, and upregulates relative expression of Bcl-2 by LPS-activated human primary monocytes in T-cell acute lymphoblastic leukemia. Bioxiv 2022. doi: 10.1101/2022.01.04.475000 [*Corresponding author]
  • Moudjahed Saleh Al-Ddafari, Chahrazed El Mezouar, Souheila Benmansour, Faiza Alddafari, Mohammed Chems-Eddine Smahi, Lozano Claire, Chantal Cognot-Pons, Pierre Portalès, Thierry Vincent, Gérard Lefranc, Mourad Aribi*. Autosomal recessive common variable immunodeficiency associated with malnutrition and severe dermatosis in a child from a double consanguineous family. Under preparation [*Corresponding author]
  • Ahlam Fatmi, Mouna Nouar, Sara Dahou, Nafissa Chabni, José Santiago Ibáñez-Cabellos, José Luis García-Giménez, Federico V. Pallardó, Mourad Aribi*. Oxidative stress inhibits corticosteroid immunosuppressive effects promoting S. aureus bloodstream infection through translocation from nearby Wharton’s gelly mucoid connective tissue, and enhances miR-23b expression by primary human endothelial cells and protection against sepsis. Under preparation [*Corresponding author]
2021
  • Sara Dahou, Mohammed Chems Eddine Smahi, Wafa Nouari, Souheila Benmansour, Lamia Ysmail-Dahlouk, Miliani Maroua, Fadela Yebdri, Nassima Fakir, Mohammed Yassine Laoufi, Mouad Chaib-Draa, Amina Tourabi, Mourad Aribi*. L-Threoascorbic acid treatment promotes S. aureus-infected primary human endothelial cells survival and function, as well as intracellular bacterial killing, and immunomodulates the release of IL-1β and soluble ICAM-1. Int Immunopharmacol 2021; 95: 107476. doi: 10.1016/j.intimp.2021.107476. [*Corresponding author]
2020
  • Zeyneb Hadjidj, Rabia Messali, Mourad Aribi*. Lack of cell movement impairs survival of peripheral blood IL-2-stimulated natural killer cell originating from solid cancer and promotes red blood cells to induce their switch into regulatory phenotype. Immunol Lett 2020; 221:6-17. doi: 10.1016/j.imlet.2020.02.002. [*Corresponding author]
  • Imène Belhassena, Wafa Nouari, Aida Messaoud, Mouna Nouar, Mohamed Brahimi, Mourad Aribi*. Aspirin enhances regulatory functional activities of monocytes and downregulates CD40 and CD16 expression in myocardial infarction autoinflammatory disease. Int Immunopharmacol 2020; 83: 106349. doi: 10.1016/j.intimp.2020.106349. [*Corresponding author]
  • Zoheir Dahmani, Lynda Addou-Klouche, Florence Gizard, Sara Dahou, Aida Messaoud, Nihel Chahinez Djebri, Mahmoud Idris Benaissti, Meriem Mostefaoui, Hadjer Terbeche, Wafa Nouari, Marwa Miliani, Gérard Lefranc, Anne Fernandez, Ned J. Lamb*, Mourad Aribi*. Metformin partially reverses the inhibitory effect of co-culture with ER-/PR-/HER2+ breast cancer cells on biomarkers of monocyte antitumor activity. PLoS One 2020; 15(10): e0240982. doi: 10.1371/journal.pone.0240982. [Corresponding authors]
  • Ahlam Fatmi, Sid Ahmed Rebiahi, Nafissa Chabni, Hanane Zerrouki, Hafsa Azzaoui, Yamina Elhabiri, Souheila Benmansour, José Santiago Ibáñez-Cabellos, Mohammed Chems Eddine Smahi, Mourad Aribi#, José Luis García-Giménez, Federico V Pallardó. miRNA-23b as a biomarker of culture-positive neonatal sepsis. Mol Med 2020; 26: 94. doi: 10.1186/s10020-020-00217-8. [#Senior authors]
2019
  • Meziane W, Mekkaoui Z, Hai I, Kacimi K, Djilali K, Touil-Boukoffa C, Lefranc G, Fernandez A, Lamb N, Mennechet F, Aribi M*. Combination of metformin with sodium selenite induces a functional phenotypic switch of human GM-CSF monocyte-derived macrophages. Int Immunopharmacol 2019; 73: 212-224. doi: 10.1016/j.intimp.2019.05.004. [*Corresponding author]
  • Hamouda L, Miliani M, Hadjidj Z, Messali R, Aribi M*. Rituximab treatment modulates the release of hydrogen peroxide and the production of proinflammatory cytokines by monocyte at the onset of type 1 diabetes. Endocr Metab Immune Disord Drug Targets 2019; 19: 643-655. doi: 10.2174/1871530319666190215153213. [*Corresponding author]
  • Saadi W, Kermezli Y, Dao LTM, Mathieu E, Santiago-Algarra D, Manosalva I, Torres M, Belhocine M, Pradel L, Loriod B, Aribi M#, Puthier D, Spicuglia S. A critical regulator of Bcl2 revealed by systematic transcript discovery of lncRNAs associated with T-cell differentiation. Sci Rep 2019; 9: 4707. doi: 10.1038/s41598-019-41247-5. [#Thesis supervisor]
  • Kermezli Y, Saadi W, Belhocine M, Mathieu EL, Garibal MA, Asnafi V, Aribi M#, Spicuglia S, Puthier D. A comprehensive catalog of LncRNAs expressed in T-cell acute lymphoblastic leukemia. Leuk Lymphoma 2019; 60: 2002-2014. doi: 10.1080/10428194.2018.1551534. [#Senior author – Thesis supervisor]
  • Lopez F, Charbonnier G, Kermezli Y, Belhocine M, Ferré Q, Zweig N, Aribi M, Gonzalez A, Spicuglia S, Puthier D. Explore, edit and leverage genomic annotations using Python GTF toolkit. Bioinformatics 2019; 35: 3487-3488. doi: 10.1093/bioinformatics/btz116.
2018
  • Maroua Miliani, Mouna Nouar, Mourad Aribi*. Thymoquinone potently enhances the activities of classically activated macrophages pulsed with necrotic jurkat cell lysates and the production of antitumor Th1-/M1-Related cytokines. J Interferon Cytokine Res 2018; 38: 539-551. doi: 10.1089/jir.2018.0010. doi: 10.1089/jir.2018.0010. [*Corresponding author]
  • Mourad Aribi*. Macrophage Bactericidal Assays. Methods Mol Biol 2018; 1784:135-149. doi: 10.1007/978-1-4939-7837-3_14. [*Corresponding author]
2017
  • Ibtissem Benghalem, Warda Meziane, Zeyneb Hadjidj, Ahmed Belamri, Kheira Mouhadjer, Mourad Aribi*. High-density lipoprotein immunomodulates the functional activities of macrophage and cytokines produced during ex vivo macrophage-CD4+ T cell crosstalk at the recent-onset human type 1 diabetes. Cytokine 2017; 96: 59-70. doi: 10.1016/j.cyto.2017.03.001. [*Corresponding author]
  • Nabila Brahami, Selvakumar Subramaniam, Moudjahed Saleh Al-Ddafari, Cecile Elkaim, Pierre-Olivier Harmand, Badr-Eddine Sari, Gérard Lefranc, Mourad Aribi*. Facial cutaneo-mucosal venous malformations can develop independently of mutation of TEK gene but may be associated with excessive expression of Src and p-Src. J Negat Results Biomed 2017; 16:9. doi: 10.1186/s12952-017-0072-5. [*Corresponding author]
  • Ibtissem Benghalem, Warda Meziane, Zineb Hadjidj, Ahamed Belamri, Kheira Mouhadjer, Mourad Aribi*. Ex vivo evaluation of the effect of high-density lipoprotein on the functional activities of macrophage in human early type 1 diabetes. Eur J Immunol 2017; 47 (Suppl 2): 126. doi: 10.1002/eji.201770300. [*Corresponding author]
2016
  • Lamia Ysmail-Dahlouk, Wafa Nouari, Mourad Aribi*. 1,25-dihydroxyvitamin D3 down-modulates proinflammatory cytokines and nitric oxide and enhances monocyte-expressed STAT6 at the recent-onset type 1 diabetes. Immunol Lett 2016; 179: 122-30. doi:10.1016/j.imlet.2016.10.002. [*Corresponding author]
  • Selvakumar Subramaniam, Mehmet Hakan Ozdener, Souleymane Abdoul-Azize, Katsuyoshi Saito, Bilal Malik, Guillaume Maquart, Toshihiro Hashimoto, Philippe Marambaud, Mourad Aribi, Michael G. Tordoff, Philippe Besnard, Naim Akhtar Khan. ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J 2016; 30: 3489-3500.
  • Chahinez Aboura, Tarik Mohammed Touaoula, Mourad Aribi#. The pulse vaccination effects in mammary carcinoma. Int J Biomath 2016; 1750036: 1-21.doi: 10.1142/S179352451750036X. [#Supervisor of immunological aspect]
  •  Wafa Nouari, Lamia Ysmail-Dahlouk,  Mourad Aribi*. Vitamin D3 enhances bactericidal activity of macrophage against Pseudomonas aeruginosa. Int Immunopharmacol 2016; 30: 94-101. doi:10.1016/j.intimp.2015.11.033.  [*Corresponding author]
  • Mustapha Haddouche, Warda Meziane, Zeyneb Hadjidj, Naima Mesli, Mourad Aribi*. Clinical association of baseline levels of conjugated dienes in low-density lipoprotein and nitric oxide with aggressive B-cell non-Hodgkin lymphoma and their relationship with immunoglobulins and Th1-to-Th2 ratio. J Blood Med 2016; 7: 111-9. doi: 10.2147/JBM.S103967.  [*Corresponding author]
  • Nesrine Remla, Zeyneb Hadjidj, Kamel Ghezzaz, Soraya Moulessehoul, Mourad Aribi*. Increased gustatory response score in obesity and association levels with IL-6 and leptin. J Nutr Metab 2016; 2016: 7924052. doi:10.1155/2016/7924052.  [*Corresponding author]
2015
  • Mourad Aribi*, Warda Meziane, Salim Habi, Yasser Boulatika, Hélène Marchandin, Jean-Luc Aymeric. Macrophage bactericidal activities against Staphylococcus aureus are enhanced in vivo by selenium supplementation in a dose-dependent manner. PLOS One 2015; 10(9): e0135515. doi:10.1371/journal.pone.0135515.  [*Corresponding author]
  • Meriem Rabia Zahzeh, Bouchra Loukidi, Warda Meziane, Mustapha Haddouche, Naima Mesli, Zahia Zouaoui, Mourad Aribi*. Relationship between NADPH and Th1/Th2 ratio in patients with non-Hodgkin lymphoma exposed to pesticides. J Blood Med 2015; 6: 99-107. doi: 10.2147/JBM.S78759.  [*Corresponding author]
2014
  • M Smahi, M Aribi, L Ysmaildahlok, L Hamouda, W Meziane. Nitric oxide, immunoglobulins and lipid peroxidation in type 1 diabetic children. Arch Dis Child 2014; 99 (Suppl 2): A267. doi: 10.1136/archdischild-2014-307384.725.
  • M Smahi, M Aribi, L Hamouda, L Labadi, L Ysmaildahlok, S Bendeddeouche. Zinc and copper disorders in children with diabetes type 1. Arch Dis Child 2014; 99 (Suppl 2): A266-7. doi: 10.1136/archdischild-2014-307384.724.
  • MC Smahi, M Haddouche, M Aribi. Alteration of antioxidant defense status in macrosomia. Arch Dis Child 2014; 99 (Suppl 2): A486.
  • MA Chahinez Aboura, MT Touaoula. M Aribi. The pulse vaccination effects in mammary carcinoma: Mathematical Modeling. Front Immunol 2014; doi:10.3389/conf.fimmu.2014.04.00036.
  • Houria Messaoudi, Mourad Aribi*. Assessment of nutritional status and frequency of monoclonal antibodies in patients with multiple myeloma subject to chemotherapy. Front Immunol 2014; doi: 10.3389/conf.fimmu.2014.04.00033.  [*Corresponding author]
  • Kheir Eddine Kerboua, Zineb Hadjidj, Warda Meziane, Amina Boumediene, Mourad Aribi*. The yin and yang of the terminal non-lytic complement pathway. Front Immunol 2014; doi: 10.3389/conf.fimmu.2014.04.00032.  [*Corresponding author]
  • Fethi Benbelaid, Monaim Khadir, Sid-Ahmed Rebiahi, Mourad Aribi*. Study of the inflammatory response in patients with cervicofacial cellulitis. Front Immunol 2014; doi: 10.3389/conf.fimmu.2014.04.00031.  [*Corresponding author]
  • Bouchra Loukidi, Meriem Zeblah, Warda Meziane, Zineb Hadjidj, Kheir Eddine Kerboua, Nadjet Etchiali, Mustapha Haddouche, Mourad Aribi*. Nitrogen stress and complement C3 in newborn pre-eclamptic mothers in the province of Tlemcen. Front Immunol 2014; doi: 10.3389/conf.fimmu.2014.04.00030.  [*Corresponding author]
  • Kheir Eddine Kerboua, Warda Meziane, Zineb Hadjidj, Amina Bouemediene, Mourad Aribi*. Oxidative stress: the big bang of the complement-mediated pathologies. Front Immunol 2014; 10.3389/conf.fimmu.2014.04.00028.  [*Corresponding author]
  • Kheir Eddine Kerboua, Samia Chaib, Warda Meziane, Amina Boumediene, Mourad Aribi*. Complement-systemic lupus erythematosus controversy in Algerian women. Front Immunol 2014; doi: 10.3389/conf.fimmu.2014.04.00027.  [*Corresponding author]
  • Kheir Eddine Kerboua, Warda Meziane, Bey Baba-Hamed, Amina Boumediene, Mourad Aribi*. Complement-related Innovations: From the immunology laboratories to biotechnology companies. Front Immunol 2014; doi: 10.3389/conf.fimmu.2014.04.00026.  [*Corresponding author]
2013
  • Ouahiba Khaib Dit Naib, Mourad Aribi*, Aicha Idder, Amel Chiali, Hakim Sairi, Isabelle Touitou, Gérard Lefranc, Mouna Barat-Houari. Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria. Front Immunol 2013; 4: 342. doi: 10.3389/fimmu.2013.00342.  [*Corresponding author]
  • Nabila Brahami, Mourad Aribi*, Badr-Eddine Sari, Philippe Khau Van Kien, Isabelle Touitou, Gerard Lefranc, Mouna Barat-Houari. Lack of TEK gene mutation in patients with cutaneomucosal venous malformations from the North-Western region of Algeria.  Genet Res Int 2013; 2013: 784789. doi:10.1155/2013/784789.  [*Corresponding author]
  • Ouahiba Khaib Dit Naib, Mourad Aribi, Aicha Idder, Amel Chiali, Hakim Sairi, Isabelle Touitou, Gérard Lefranc, Mouna Barat-Houari. IL10 SNPs associated with BD in Western Algeria. Pediatric Rheumatology 2013; 11 (Suppl 1): A205.
  • Mourad Aribi*, Ibtissem Benghalem, Khaled Labadi, Linda Hamouda, Warda Meziane, Mohammed Lammani. Immunoglobulins, Zn and NO in newly diagnosed children with type 1 diabetes. Front Immunol 2013; doi: 10.3389/conf.fimmu.2013.02.01105.  [*Corresponding author]
  • Mourad Aribi*, Meriem Rabia Zahzeh, Zineb Hadjidj, Chahinez Triqui, Naima Mesli. Relationship between selenium intake and inflammatory markers in newly-diagnosed patients with B-cell non-Hodgkin lymphoma. Front Immunol 2013; doi: 10.3389/conf.fimmu.2013.02.01106.  [*Corresponding author]
2012
  • Aribi M*, Haddouche M. Biomarkers of Oxidative/Antioxidative Balance in Macrosomia. Arch Dis Child 2012; 97: A408. doi:10.1136/archdischild-2012-302724.1435.  [*Corresponding author]
  •  Aribi M*, Senouci-Bereksi S, Haddouche M, Mesli N. Vitamin D intake and light chain-IgG monoclonal antibodies in patients with multiple myeloma. Fundam Clin Pharmacol 2012; 26 (Suppl I): S64-65.  [*Corresponding author]
2011
  • Mustapha Haddouche, Mourad Aribi*, Soraya Moulessehoul, Mohammed Chems-Eddine Ismet Smahi, Mohammed Lammani, Mohammed Benyoucef. Alteration of antioxidant defense status precedes humoral immune response abnormalities in macrosomia. Med Sci Monit 2011; 17: CR650-6.  [*Corresponding author]
  • Karaouzene N, Merzouk H, Aribi M, Merzouk SA, Yahia Berrouiguet A, Tessier C, Narce M. Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: A comparison of older with young men. Nutr Metab Cardiovasc Dis 2011; 21: 792-9.  
BEFORE 2011
2010
  • Clin Biochem 2010; 43: 942-7.
  • J Cancer Res Ther 2010; 6: 41-6.
  • Pediatric Research 2010; Supp 1: 355.
2009
  • Am J Case Rep 2009; 10: CR205-8.
  • Eur J Immunol 2009; 39 (Suppl 1): S706-7.
  • Ann Dermatol Venereol 2009; 136 (Suppl 2): F156-7.  
2008
  • Curr Diab Rev 2008; 4: 110-21.
  • Open Genomics J 2008; 1: 1-5.
  • Arch Dis Child 2008; 93 (Suppl II): A387-8.
2007
  • Med Sci Monit 2007; 13: CR372-378.
2006
  • Fundam Clin Pharmacol 2006; 20 (Suppl): 222. doi: 10.1111/j.1472-8206.2006.00409.x.
2004
  • BMC Genet 2004; 5: 24. doi:10.1186/1471-2156-5-24.

Livres | Books

  • Mourad Aribi (2020). Normal and Malignant B-Cell. doi: 10.5772/intechopen.78445, Number of Pages, 162. ISBN: 978-1-78985-601-9, Print ISBN: 978-1-78985-430-5, eBook (PDF) ISBN: 978-1-78985-602-6. Content
Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology.

  • Mourad Aribi (2018). Natural killer cells. Intech, doi: 10.5772/66568. Number of Pages, 208. ISBN: 978-953-51-3672-9, Print ISBN: 978-953-51-3671-2, eBook (PDF) ISBN 978-953-51-4573-8.  Cover page
The book Natural Killer Cells is the result of a collective work that addresses in a clear and comprehensive way for readers and through as many sensuous details as possible, the most and various fundamental aspects of natural killer cells, as well as their clinical applications in cancer immunotherapy. This book will serve as an invaluable resource and pedagogical support for clinicians, researchers, basic scientists, immunology and immunopathology lecturers, as well as for students in biology and medicine, especially the ones with an advanced understanding of immunology.
 
  •  Mourad Aribi (2017). Immunopathogenesis and immune-based therapy for selected autoimmune disorders. InTech, doi: 10.5772/63032, Number of Pages, 182. ISBN 978-953-51-3022-2, Print ISBN 978-953-51-3021-5. eBook (PDF) ISBN 978-953-51-5479-2. Cover page
The book Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders is a synthesis work that discusses two main aspects of autoimmunity: Immunopathogenesis and therapeutic approaches essentially based on the immunotherapies. This book deals with different topics on a number of autoimmune disorders, including type 1 diabetes, autoimmune cardiomyopathy, autoimmunity of gastrointestinal tract, systemic sclerosis, and myasthenia gravis. This book will be useful to clinicians, biologists, researchers, teachers, and students who are interested in immunology and immunopathology.

Chapitres de Livre | Book chapters

Communications

  • 44 International communications
  • 35 National communications

Selected communications and conferences of the four years (before the COVID-19 pandemic). *Presenter/Speaker

Mourad Aribi. Antibody Production. Leaflet
2023-01-16
Tlemcen, Algeria           
[Mini-Symposium and Workshop on ImmunoTechnology. Prochima-Sigma, Tlemcen, January 16, 2023]
 
Imène Belhassenaa, Wafa Nouari, Aida Messaoud, Mouna Nouar, Mohamed Brahimi, Sid-Ahmed Chawki Lamarac, Mourad Aribi. Effect of aspirin on oxidative burst of monocytes during myocardial infarction autoinflammatory disease.
2023-06-07 – 2023-06-06
Tiaret, Algeria                 
[NS-OSNH. First National Seminar on “Oxidative stress, Nutrition and Health”, Tiaret, Ibn Khaldoun University, Algeria, 6-7 June, 2022]
 
Mourad Aribi. Sleep deprivation and immunity.
2023-02-19
Tlemcen, Algeria           
[2nd Scientific Event of immunoSPACE Club │Insomnia Event. Faculty SNV/STU. University of Tlemcen, February 19, 2023]
 
Mourad Aribi, Zeneb Hadjidj, Rabia Messali. Cell stagnation results in impaired function of natural killer cells from solid tumors, and effects of interplay with red blood cells.
2022-11-24 – 2022-11-22
Nice, France                   
[SFI-AFC 2022. the Annual Meetings of the French Society for Immunology (SFI) and the French Cytometry Association (AFC), Nice, Palais des Congrès et des Expositions, France, 22-24 November, 2022]
 
Mourad Aribi. Overview on the Immune System.
2023-10-25
Tlemcen, Algeria           
[1st Scientific Event of immunoSPACE Club │Open Day. Faculty SNV/STU. University of Tlemcen, October 25, 2023]
 
Maroua Miliani, Mouna Nouar, Océane Paris, Gérard Lefranc, Franck Mennechet, Mourad Aribi. Effects of thymoquinone on the production of Th1/M1-related cytokines in the co-culture system of human necrotic Jurkat T cell line lysates (NecrJCL)-pulsed classically activated macrophage with autologuous CD4+ T-cells.
2022-06-25 – 2022-06-24
Algiers, Algeria              
[SAI 2022. 10ème Congrès National d’Immunologie, Algiers, Hôtel El Aurassi, Algeria, 24-25 June, 2022]
 
Imène Belhassenaa, Wafa Nouari, Aida Messaoud, Mouna Nouar, Mohamed Brahimi, Sid-Ahmed Chawki Lamarac, Mourad Aribi. Aspirin induces downregulation at a dose-dependent manner of intracellular levels of glucose in monocytes during myocardial infarction autoinflammatory disease.
2022-11-18 – 2022-11-17
Oran, Algeria                  
[ACDM 2022. 7ème Congrès International Pathologies Cardio-Métaboliques, Oran, Bay Ex Sheraton, Algeria, 17-18 November, 2022]
 
Wiam Saadi, Yasmina Kermezli, Lan T.M. Dao, Evelyne Mathieu, David Santiago-Algarra, Magali Torres, Mohamed Belhocine, Lydie Pradel, Beatrice Loriod, Mourad Aribi, Denis Puthier, Salvatore Spicuglia. Dissection of LncRNA associated with T cell differentiation revealed a critical regulator of Bcl2.
2021-07-03
Algiers, Algeria              
[SABGM 2021. 5ème Congrès de Biochimie et de Génétique Médicales, Algiers, Hôtel Mercure, Algeria, Jully 3, 2021]

Mourad Aribi*. 9CI-O-4.2-2020 Inflammatory bowel diseases & immunotherapies.

2020-02-27
Tlemcen, Algeria
[9th Scientific Event in Immunology │Skin, Mucous Membranes & Immunity. Laboratory of Applied Molecular Biology & Immunology, W0414100. University of Tlemcen, February 27, 2020]  
 
W. Meziane, Z. Mekkaoui, C. Touil-Boukoffa, G. Lefranc, A. Fernandez, N. Lamb, F. J. Mennechet, M. Aribi*. Combination of metformin with sodium selenite induces a functional phenotypic switch of human GM-CSF monocyte-derived macrophages.
2019-11-14 – 2019-11-12
Nantes, France                
[SFI 2019. 52nd Annual Meeting of the French Society for Immunology, Cité des Congrès de Nantes, France, 12-14 november, 2019]

Mourad Aribi*. Tumor antigen cell lysate-pulsed classically activated M1 macrophages for vaccination against cancer.
2019-11-8 – 2019-11-7
Oran, Algeria
[3rd International Conference │ Biotechnology and Cancer. Biosciences 2019. Oran, Algeria. 7-8 december, 2019.]

L. Hamouda, M. Miliani, Z. Hadjidj, R. Messali, M. Aribi*. Rituximab treatment reverses the abnormal functional activities of monocyte at the onset of human type 1 diabetes.
2019-11-14 – 2019-11-12
Nantes, France                
[SFI 2019. 52nd Annual Meeting of the French Society for Immunology, Cité des Congrès de Nantes, France, 12-14 novemer, 2019]
 
Z. Mekkaoui, M. ARIBI*, N. Sari, F. Rostane, I. Bali, C. EL Mezouar, Z. Hadjidj, R. Messali. Sodium selenite increases the immunotherapeutic effect of metformin on monocyte during T-cell acute lymphoblastic leukemia.
2019-11-14 – 2019-11-12
Nantes, France                
[SFI 2019. 52nd Annual Meeting of the French Society for Immunology, Cité des Congrès de Nantes, France, 12-14 novemer, 2019]
 
Z. Mekkaoui, M. Aribi*, W. Meziane, S. Dahou, M. C.-E. Smahi. Ascorbate effects on the expression of soluble adhesion molecules and cytokines during S. aureus-HUVEC interaction.
2019-11-14 – 2019-11-12
Nantes, France  
[SFI 2019. 52nd Annual Meeting of the French Society for Immunology, Cité des Congrès de Nantes, France, 12-14 novemer, 2019]
 
Mourad Aribi*. Immunological interest of the pulsation of classically activated proinflammatory/killer macrophages using necrotic Jurkat T cell lysates and adjuvant biphasic role of thymoquinone.
2018-11-16 – 2018-11-15
Reims, France                  
[11ème Forum du Cancéropôle Est, Reims, France, 15-16 novembre, 2018]
 
Sara Dahou, Mohammed Chems-Eddine Smahi, Zoheir Dahmani, Wafa Nouari, Lamia Ysmail-Dahlouk, Mourad Aribi*. Ex vivo effect of vitamin C on endothelial cell production of nitric oxide.
2018-5-3 – 2018-5-4
Tlemcen, Algeria
[12ème rencontre pédiatrique de Tlemcen. Cardiologie Pédiatrique. May 3-4, 2018, Rennaissance Hotel, Tlemcen, Algeria]
 
Maroua Miliani*, Mouna Nouar, Mourad Aribi. Effects of thymoquinone on arginase activity of classically activated macrophage pulsed with necrotic Jurkat T cell line lysates (NECRJCL).
2018-3-20 – 2018-3-22
Bizerte, Tunisia
[7th International Science & Environment Symposium. March 20-22, 2018, Bizerte, Tunisia]

Ibtissem Benghalem, Warda Meziane, Zineb Hadjidj, Ahamed Belamri, Kheira Mouhadjer, Mourad Aribi*. Ex vivo evaluation of the effect of high-density lipoprotein on the functional activities of macrophage in human early type 1 diabetes.
2017-9-12 – 2017-9-15
Erlangen, Germany
[47th Annual Meeting of the German Society for Immunology (DGFI). 12–15 September 2017, Erlangen, Germany]
 
Mourad Aribi*. Microbiote, food antigens & mucosal immunity.
2017-3-5 Part I
2017-3-7 Part II
2017-3-12 Part III
Tlemcen, Algeria
[Upgrade courses. Microbiote, antigènes alimentaires & immunité mucosale. Conférences plénières de mise à niveau. March 5th, 7th and 12th, 2017, Tlemcen, Algeria. Programme].
 
Lamia Ysmail-Dahlouk, Mohammed Chems-Eddine Smahi, Wafa Nouari, Mourad Aribi*. Immunoregulatory effect of vitamin D3 on Th17/Treg balance during type 1 diabetes.
2017-3-2 – 2017-3-4
Amsterdam, the Netherlands
[4th International Conference on Nutrition & Growth. March 2-4, 2017, Amsterdam, the Nederlands]
 
Mohammed Chems-Eddine Smahi, Lamia Ysmail-Dahlouk, Mourad Aribi*. Effect of 1,25- dihydroxyvitamin D3 on the Th1/Th2 balance and nitric oxide in type 1 diabetes. 
2017-3-2 – 2017-3-4
Amsterdam, the Netherlands
[4th International Conference on Nutrition & Growth. March 2-4, 2017, Amsterdam, the Nederlands]
 
Wafa Nouari, Lamia Ysmail-Dahlouk, Mourad Aribi*. Phagocytosis and respiratory burst in 1,25(OH)2D3-treated human macrophages during P. aeruginosa infection.
2016-9-27 – 2016-9-30
Hamburg, Germany
[46th Annual Meeting German Society for Immunology (DGfI). September 27-30, 2016, Hamburg, Germany]
 
Mustapha Haddouche, Meziane Warda, Mourad Aribi*. LDL-BCD and pathogenesis of aggressive B-cell non-Hodgkin lymphoma.
2016-9-27 – 2016-9-30
Hamburg, Germany
[46th Annual Meeting German Society for Immunology (DGfI). September 27-30, 2016, Hamburg, Germany]

Projets De Recherche | Research Projects

Table 1. Summary of Research Contract.
Table 1. Summary of Research Contract.
ProjectDirector/Principal InvestigatorCodeContracting AgencyYear
PHC TassiliMourad Aribi (Algeria) & Salvatore Spicuglia (France)CMEP: 15MDU935
ÉGIDE/Campus France: 33277RH		Algeria: MESRS
 
France: MAEDI and MENESR		2015
PHC TassiliMourad Aribi (Algeria) & Gérard Lefranc (France)CMEP: 10MDU794
ÉGIDE/Campus France: 22097UJ
Algeria: MESRS

France : MAEDI and MENESR		2010
FNRMourad Aribi21/05/2019 ATRSS 2020
PNRMourad Aribi04/07/04/14/038
DGRSDT
2017
PNRMourad Aribi365/ANDRS/2011 (18/u13/1478)
ANDRS2011
PNRSari Badr-Eddine (PI) & Mourad Aribi (co-PI)18/X/5151ANDRS2011
CNEPRUMourad AribiD01N01UN130120150009MESRS2016
CNEPRUMourad AribiD01N01UN130120140040MESRS2014
CNEPRUMourad AribiI02020100078MESRS2011
CNEPRUFouad Hadj-Allal (PI), Sari Badr-Eddine & Mourad Aribi (co-PI)I02020070014MESRS2007
PRFUMourad AribiD01N01UN130120200004MESRS2020
PRFUMohammed Chems Eddine Smahi (PI), Farah Djelti & Mourad Aribi (co-PI)D01N01UN130120230011MESRS2023
Public Health Project – FNRMourad AribiBudget notification ref. 211/D.G.R.S.D.T./D.D.S.S.T./2020DGRSDT2020
TOTAL NUMBER OF PROJECTS (FROM 2007 TO 2022): 13
ATRSS: Agence Thématique de Recherche en Sciences de la Santé [Thematic Agency for Research in Health Sciences]
CNEPRU: Commission Nationale d'Evaluation des Projets de Recherche Universitaire [National Commission for the Evaluation of University Research Projects]
DGRSDT: Direction Générale de la Recherche Scientifique et du Développement Technologique [Directorate General for Scientific Research and Technological Development]
FNR: Fond National de la Recherche Scientifique et du Développement Technologique [National Fund for Scientific Research and Technological Development]
MAEDI: Ministère des Affaires Étrangères et du Développement International  [Ministry of Foreign Affairs and International Development]
MENESR: Ministère de l’Éducation Nationale, de l’Enseignement Supérieur et de la Recherche Français [French Ministry of National Education, Higher Education and Research]
MESRS: Ministère de l'Enseignement Supérieur et de la Recherche Scientifique [Ministry of Higher Education and Scientific Research]
PHC Tassili: Partenariats Hubert Curien - Tassili
PNR: Projet National de Recherche [National Research Project]
PRFU: Projets de Recherche-Formation Universitaire [University Research-Training Projects]

Collaborations Internationales 

L'ensemble des collaborations, concrétisées avec des partenaires internationaux par le Pr Mourad Aribi, Chef d'Equipe W0414101 et Directeur de Laboratoire, s'inscrivent dans le cadre de Stages de Haut Niveau, dédiés aux étudiants de Licence, Master et Doctorat Immunologie, ou dans la Recherche sur des thématiques complémentaires (cf. Figure 4). 

International Collaborations

All the collaborations presented here, concretized by Pr Mourad Aribi, Head of Team W0414101 and Laboratory Director, are part of High Level Internships, dedicated to Bachelor's, Master's and PhD students in Immunology, or in Scientific Research on complementary themes with International Partnerships (see Table 2).

Figure 4. Principaux partenaires de collaborations internationales.  | Figure 4. Main partners of international collaborations.

Organisation d'Ateliers de Travail & d'Evènements scientifiques 

  • 13th Scientific Event in Immunology │2nd International Congress of Immunology and Molecular Immunopathology (CIMIP2024). CIMIP April 30-May 3, 2024. Medea, Algeria. (Upcoming Congress) (2024-4-30 – 2021-5-3. Medea, Algeria) 

  • 12th Scientific Event in Immunology │6th Workshop of BIOMOLIM Laboratory: Immune Cell Landscape: Immunofluorescence Analysis of Single-Cell from BIOMOLIM Laboratory's Cell Imaging Station. Laboratory of Applied Molecular Biology & Immunology (BIOMOLIM), W0414100. University of Tlemcen (2023-12-24. Tlemcen, Algeria).  
 
  • 11th Scientific Event in Immunology │5th Workshop of BIOMOLIM Laboratory: IT Resources for Education and Research in Immunology during the COVID-19 Pandemic. Laboratory of Applied Molecular Biology & Immunology (BIOMOLIM), W0414100. University of Tlemcen (2021-05-09 – 2021 -05-08. Tlemcen, Algeria)
 
  • 10th Scientific Event in Immunology │4th Workshop of BIOMOLIM Laboratory: Bibliographic Management for Immunologists. Laboratory of Applied Molecular Biology & Immunology (BIOMOLIM), W0414100. University of Tlemcen (2021-04-10. Tlemcen, Algeria)
  • 9th Scientific Event in Immunology │Skin, Mucous Membranes & Immunity. Laboratory of Applied Molecular Biology & Immunology (BIOMOLIM), W0414100. University of Tlemcen (2020-02-27. Tlemcen, Algeria)
 
  • 3rd Workshop of Immunology. 2nd Bioinformatics and Genomics Training - 1st Workshop of Immunoinformatics: Transcriptomics analysis by high speed approaches. BIOMOLIM Laboratory and Transcriptomic and Genomic Marseille-Luminy (TGML) Team (2016-05-28 – 2016-06-03. Tlemcen, Algeria) IIIrd Workshop
  •  1st Bioinformatics and Genomics Training. BIOMOLIM Laboratory and BHK Team (2015-03-12 – 2015-03-16. Tlemcen, Algeria  Link
 
  • 2nd Annual Scientific Day of PhD candidates. BIOMOLIM Laboratory (2015-02-26. Tlemcen, Algeria)
 
  • 1st International Congress of Immunology and Molecular Immunopathology (CIMIP2014) (2014-10-17 – 2014-10-20 (Tlemcen, Algeria. CIMIP2014
  •  1st Annual Scientific Day of PhD candidates. BIOMOLIM Laboratory. Tlemcen, Algeria (2014-02-19. Tlemcen, Algeria)
 
  • 1st National Seminar on Molecular Biology and Biology Equipment - Diagnosis and Research. In collaboration with the HTDS Society and its Technology Partners – Applied Biosystems, Invitrogen, Life Technologies [PerkinElmer, APELEX, Biochrom, Caliper LifeSciences] –  (2013-02-19. Tlemcen, Algeria)
 
  • 2nd Workshop of Immunology. Cellular Immunology and Molecular Biology (ICBM2013) (2013-05-05 – 2013-05-07. Tlemcen, Algeria). ICMB2013   Préambule (Objectifs du Workshop)
  •  1st Workshop of Immunology. Monoclonal Antibodies: Immunodetection and immunotechnology (2011-05-02 – 2011-05-03. Tlemcen, Algeria). Access to Pictures

Prix & Distinction | Awards & Achievements


The 2016 Algerian Paper of the Year Award in Medicine, Pharmacy & Veterinary Sciences

The winners of the 2016 Algerian Paper of the Year Award were announced by the Algerian Network for Academics, Scientists and Researchers. An interaction space to discover, share and inspire Algerian intellect.


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